منابع مشابه
Rhox: A New Homeobox Gene Cluster
Homeobox genes encode transcription factors notable for their ability to regulate embryogenesis. Here, we report the discovery of a cluster of 12 related homeobox genes on the X chromosome expressed in male and female reproductive tissues in adult mice. These reproductive homeobox on the X chromosome (Rhox) genes are expressed in a cell type-specific manner; several are hormonally regulated, an...
متن کاملSupplemental Data Rhox: A New Homeobox Gene Cluster
Cell Type Specificity of Rhox Gene Expression in Testes To identify the cell types in the testis that express the Rhox genes, we purified testicular cell fractions enriched for Sertoli and interstitial (e.g., Leydig) cells. Although it is not possible to generate entirely pure populations of these cell types, our fractions were substantially enriched, based on the relative levels of Sertoli and...
متن کاملEpigenetic regulation of the RHOX homeobox gene cluster and its association with human male infertility.
The X-linked RHOX cluster encodes a set of homeobox genes that are selectively expressed in the reproductive tract. Members of the RHOX cluster regulate target genes important for spermatogenesis promote male fertility in mice. Studies show that demethylating agents strongly upregulate the expression of mouse Rhox genes, suggesting that they are regulated by DNA methylation. However, whether th...
متن کاملThe rhox homeobox gene cluster is imprinted and selectively targeted for regulation by histone h1 and DNA methylation.
Histone H1 is an abundant and essential component of chromatin whose precise role in regulating gene expression is poorly understood. Here, we report that a major target of H1-mediated regulation in embryonic stem (ES) cells is the X-linked Rhox homeobox gene cluster. To address the underlying mechanism, we examined the founding member of the Rhox gene cluster-Rhox5-and found that its distal pr...
متن کاملHomeobox Galore: When Reproduction Goes RHOX and Roll
Homeobox transcription factors exert essential roles in embryogenesis and are thought to govern regenerative cell differentiation. In this issue of Cell, MacLean and colleagues (MacLean et al., 2005) describe a new homeobox gene cluster composed of genes selectively expressed in reproductive tissues. Remarkably, the cluster is on the X chromosome, and the genes display a colinear pattern of exp...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2004.12.022